The Substance is a body horror movie. Elisabeth Sparkles, once a famous actress, feels that her age is impeding her life. So when she is offered something that is supposed to make her young again, she decides to try it. The service splits Elisabeth into both her old self and a younger self named Sue. One week Elisabeth is awake and able to live her life and the next week Sue is awake. Soon enough both halves begin to resent the other. The Substance was released in 2024. It was directed by Coralie Fargeat. It stars Demi Moore, Margaret Qualley, and Dennis Quaid.

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