I'm only just in my second semester of college but it would have to be my Abnormal Psychology class. It's my major but it's really hard for me since we have to memorize a bunch from the DSM-5. Probably will end up with the lowest grade in probably the past 8 years in that class. x.x Doesn't help that the professor doesn't give all of her notes online.

Probably my advanced Spanish composition class. Spanish is not my native language, and the professor was super strict. It was the only class in college where I made a B+. However, I took another advanced Spanish class with the same professor a year later and made an A because I finally knew how to write essays to her standards.

I had to take a science course for a credit hour and I got stuck in some sort of Molecular Physics class. I wasn't sure what I had got myself into and then it hit me all at once!

Biochemistry. It didn't help that the teacher was literally awful. Physics was also super difficult. -.-

Clinical 2. It was the medical assistant course where we actually started to have to draw blood. UM. No. I couldn't do it. I switched majors quick.

Organic Chemistry... But that'll probably change if I end up going to med school LOL

I think I have to go with history, but only because we had a stupid stubborn teacher, that COULD NOT for the life of him teach anyone anything, EVER! Also it was a course I was forced to take, and I've never been much for a fact heavy course :)

Oh gosh, probably my English Syntax course. I was just so bored I couldn't really pay attention or put any effort in. On the flip side, the worst grade I ever got was in my Sociology of Surveillance course. It was super interesting and I tried really hard, but no matter what I did I couldn't seem to get a good grade in it?

I would say a toss up between chemistry and thermodynamics in material science. Chemistry I always hated and the professor was horrible so thankfully I only needed one semester. As for thermodynamics, it was a graduate course and I had no undergraduate background in material science nor thermodynamics so I worked my ass off for that class. I was always a chapter ahead of the class and luckily I had a friend who graduated with a degree in materials engineering that was able to help me.

I'd have to say that Chemistry at University gave me the hardest kick to the face I've ever had. I literally just cried staring at the book, absolutely lost on what the heck I was looking at.

However, the moment I took Chemistry at a community college, the teacher was great, and suddenly the entire subject matter made perfect sense to me... now, it's pretty darn cool.

Your own study efforts, teacher assistance, and maturity can really change your mind.

Biochem. It is the only class that I got a D in... =/ It was like a slap in the face.

Molecular and Organic Chemistry. Welcome to a first year biology module that even the third year chemistry students can't help you with. I would rather eat my statistics book (no mean feat) than do that module again.

Human Anatomy and Physiology was tough because I took it over the summer, so it was a lot of information delivered very quickly. The practical part of the exam was especially tricky; we had to go from station to station identifying bones and muscles, and tissue cells under a microscope. Fascinating course, though!

I'm on my third semester in a Mechanical Engineering major, and Differential Equations is, hands down, the hardest course I've ever made - and I'm still experiencing it. Here, college works a bit differently, and in High School we don't have any kind of introdution to Derivatives and Integrals, so we learn it all in a course. I have always done so well in Calculus and got a slap in the face with Equations.

geomorphology, but mostly because my professor was horrible. otherwise biochem

I'm in college right now - I'm in a program that lets me take graduate level classes as an undergrad and I'd have to say the one grad class I'm taking now. It's a course on Gender, Work, and the Family. It's a really interesting course, but the professor is a stickler who wants us to be great, so she's really tough on grading. It's a bunch of work but I'm glad I'm taking the class.

Ancient Greek. Without question. Other classes had more work or higher expectations, sure, but nothing compared to the sheer stress and pain that came from Ancient Greek.

Chemistry, by far. That semester was absolutely the worst of my college career. Physics is pretty bad too - I'm taking that right now. ;_; science, in general.